Green cardamom (Elettaria cardamomum) and ginger (Zingiber officinale), known for their therapeutic uses in ancient medicine, contain phytochemicals such as limonene, eucalyptol, and gingerol, which exhibit notable anticancer and anti oxidant properties. In this study, novel cadmium sulphide quantum dots (CdS QDs) were synthesized using extracts from green cardamom fruits (CdS-Cm QDs) and ginger (CdS-Gi QDs) via a simple one-pot method at room temperature. Characterization of the synthesized QDs using X-ray diffraction (XRD) revealed their amorphous nature, while high resolution transmission electron microscopy (HR-TEM) indicated particle sizes in the range of 2–5 nm. Scanning electron microscopy (SEM) and ultraviolet-visible spectroscopy (UV-vis) further confirmed their morphology and optical proper ties. Cytotoxicity assessments using the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) assay on the human breast cancer cell line MCF-7 (Michigan Cancer Foundation-7) demonstrated an inhibitory concentration of 50% (IC50) of 39.03 µM for CdS-Cm QDs, compared to 30.76 µM for the standard drug cisplatin. Additional evalua tions using lactate dehydrogenase (LDH) and apoptosis assays indicated IC50 values of 27.3 µg/ml for CdS-Cm QDs and 63 µg/ml for CdS-Gi QDs. In vitro erythrolysis testing with AB + human blood showed that erythrocyte damage remained within acceptable limits (below 2.5%), confirming the biocompatibility of the synthesized QDs. Furthermore, the QDs exhibited significant antibacterial and antioxidant activities. While the promising biomedical applications of these CdS QDs are evident, the inherent toxicity of cadmium compounds warrants consideration. Future strategies, such as surface functionalization and biocompatible coatings, could mitigate these concerns, enhancing their clinical applicability. These findings underscore the potential of phytochemical-derived CdS QDs as multifunctional agents in anticancer study and