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Synthesis and Biological Evaluation of Novel N'(4-aryloxybenzylidene)-1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

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Category
Articles
Authors
Afsar Ali Siddiki
Publisher
Bentham
Publishing Date
01-Aug-2014
volume
17
Issue
7
Pages
630-638

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.

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