Coumarins, possesing antimicrobial activity are often used by the researchers to develop novel synthetic and semisynthetic coumarin based therapeutic agents. Molecular hybridization concept was used to design coumarin hybrid molecules. Synthesized molecules were evaluated for their invitro antibacterial activities. We designed Coumarin derivatives of diphenyl ether and oxadiazole. Most of the compounds showed antimicrobial activity against gram-positive as well as gram-negative bacteria.